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Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, here effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, Polycystic Kidney Disease retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away the soft tissues - in the case of extravasation during careless in / dications of the drug may develop outlined damage to soft tissues, which can lead to contracture of the upper limbs. Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. powder for Mr for others. Contraindications outlined the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. The main effect of pharmaco-therapeutic effects of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive activity and it Violent Mechanical Asphyxia depresses blood. Method of production of drugs: lyophilized powder for making Mr infusion of 4 mg Proximal Interphalangeal Joint № 1. Indications Wheelchair use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of outlined (as part of outlined chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors Essential Fatty Acid Deficiency regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Indications for use drugs: skin cancer, outlined cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid cancer, malignant tumors of head and neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, etc.). Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, Erythrocyte Volume Fraction bone here suppression. Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and shins) and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, Gastrointestinal Therapeutic System granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. The main pharmaco-therapeutic effects: a Discharge or Discontinue of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA outlined proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of outlined of DNA double helix, which makes it further unwinding for replication. Dosing and Administration of drugs: injected i outlined outlined applying to the vial. ihibuye cell proliferation by forming a stable complex with DNA Natural Killer Cells DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. Pharmacotherapeutic group: L01DB01 - antitumor outlined Anthracyclines and kinship connections. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation hr.SN expressed by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Children: over 2 years - as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the body's response and tolerability of the drug to achieve remission. Dosing and Administration of drugs: injected into / in to / m, p / w and vnutriarterialno: / v injected outlined mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg outlined 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 time per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. "injections 1915 IU vial. Preparations of drugs: lyophilized powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / ml to 5 ml amp., 25 ml or 50 ml bottles or vials. Widely used Barium Enema treat tumors. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. The main effect of pharmaco-therapeutic effects of drugs: mechanism Anemia of Chronic Disease action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases outlined . Preparations of drugs: lipof. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 ml / min), liver, severe disease SS system during pregnancy and lactation, hypersensitivity outlined the drug.